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MINI REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1511886
This article is part of the Research Topic Community Series in the Role of Complement in Health and Disease: Volume II View all 9 articles
Complement system in lipid-mediated pathologies
Provisionally accepted- 1 Department of Medical Biochemistry, Faculty of Medicine University of Sarajevo, Sarajevo, Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina
- 2 Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria
The complement system, a coordinator and facilitator of the innate immune response, plays an essential role in maintaining host homeostasis. It promotes clearance of pathogen-and dangerassociated molecular patterns, regulates adaptive immunity, and can modify various metabolic processes such as energy expenditure, lipid metabolism, and glucose homeostasis. In this review, we will focus on the intricate interplay between complement components and lipid metabolism. More precisely, we will display how alterations in the activation and regulation of the complement system affect pathological outcome in lipid-associated diseases, such as atherosclerosis, obesity, metabolic syndrome, age-related macular degeneration, and metabolic dysfunction-associated steatotic liver disease. In addition to that, we will present and evaluate underlying complement-mediated physiological mechanisms, observed both in vitro and in vivo. Our manuscript will demonstrate the clinical significance of the complement system as a bridging figure between innate immunity and lipid homeostasis.
Keywords: innate immunity, complement, Lipid Metabolism, lipid-mediated pathologies, complement system
Received: 15 Oct 2024; Accepted: 31 Oct 2024.
Copyright: © 2024 Alic, Dendinovic and Papac-Milicevic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Nikolina Papac-Milicevic, Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University Vienna, Vienna, Austria
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