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REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1510628
This article is part of the Research Topic Methods in Molecular Innate Immunity: 2022 View all 9 articles
Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases
Provisionally accepted
Hui Zhi
1*
Hui Fu
2*
Yunxin Zhang
1*
Ni Fan
1*
Chengcheng Zhao
3*
Yunfei Li
1*
Yujiao Sun
1*
Yingpeng Li
1*- 1 College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 2 College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 3 Experimental Teaching and Partical Training Center, Heilongjiang University of Chinese Medicine, Harbin, Jilin Province, China
The cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the production of interferons and pro-inflammatory cytokines to enhance immune defenses against tumors and pathogens. However, dysregulated activation of the STING pathway is implicated in the pathogenesis of multiple diseases, including autoinflammation, viral infections, and cancer. Traditional Chinese Medicines (TCMs), which have a long history of use, have been associated with positive effects in disease prevention and treatment. TCM formulations (e.g., Lingguizhugan Decoction, Yi-Shen-Xie-Zhuo formula) and active compounds (e.g., Glabridin, Ginsenoside Rd) can modulate the cGAS-STING signaling pathway, thereby influencing the progression of inflammatory, infectious, or oncological diseases. This review explores the mechanisms by which TCMs interact with the cGAS-STING pathway to regulate immunity, focusing on their roles in infectious diseases, malignancies, and autoimmune disorders.
Keywords: cGAS-STING pathway1, Traditional Chinese medicine2, Immunity3, disease4, Cancer5, infection6 cGAS-STING pathway1, infection6
Received: 13 Oct 2024; Accepted: 29 Nov 2024.
Copyright: © 2024 Zhi, Fu, Zhang, Fan, Zhao, Li, Sun and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hui Zhi, College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Hui Fu, College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Yunxin Zhang, College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Ni Fan, College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Chengcheng Zhao, Experimental Teaching and Partical Training Center, Heilongjiang University of Chinese Medicine, Harbin, 150040, Jilin Province, China
Yunfei Li, College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Yujiao Sun, College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Yingpeng Li, College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China
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