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MINI REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1507420
This article is part of the Research Topic Investigating Splicing Event as Therapeutic Targets in Inflammatory disease View all 3 articles
The role of splicing events in the inflammatory response of atherosclerosis: molecular mechanisms and modulation
Provisionally accepted
Aolong Wang
1
Chengzhi Wang
2
Bihan Xuan
3
Yanqin Sun
1
Bin Li
1
Qifei Zhao
1
Rui Yu
1
Xinlu Wang
1*
Mingjun Zhu
1*
Jingjing Wei
1*- 1 First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
- 2 Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
- 3 Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
Atherosclerosis is a chronic inflammatory disease characterized by persistent inflammatory responses throughout all stages of its progression. Modulating these inflammatory responses is a promising avenue for the development of cardiovascular disease therapies. Splicing events modulate gene expression and diversify protein functionality, exerting pivotal roles in the inflammatory mechanisms underlying atherosclerosis. These insights may provide novel opportunities for developing anti-inflammatory therapies for this disease. This article systematically discusses the diverse splice variants and how splicing events impact the inflammatory response in atherosclerosis via endothelial cells, macrophages, and vascular smooth muscle cells, highlighting their underlying molecular mechanisms and implications. Furthermore, this study summarizes clinical evidence supporting splicing-related molecules as diagnostic biomarkers and therapeutic targets in atherosclerosis. Lastly, we outline the current challenges and future research directions concerning splicing events and inflammatory responses in atherosclerosis. This offers a novel perspective and evidence for formulating new therapeutic strategies aimed at lowering the risk of atherosclerosis.
Keywords: Atherosclerosis, Splicing events, Inflammatory Response, Molecular mechanisms, biomarker
Received: 07 Oct 2024; Accepted: 02 Dec 2024.
Copyright: © 2024 Wang, Wang, Xuan, Sun, Li, Zhao, Yu, Wang, Zhu and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinlu Wang, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
Mingjun Zhu, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
Jingjing Wei, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
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