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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1507355
This article is part of the Research Topic Microbiome and Immunotherapy View all articles

Microbiome in urologic neoplasms: focusing on tumor immunity

Provisionally accepted
Jun Zou Jun Zou 1Baisheng Xu Baisheng Xu 2Peiyue Luo Peiyue Luo 3Tao Chen Tao Chen 3Huanglin Duan Huanglin Duan 2*
  • 1 The Affiliated Fengcheng Hospital of Yichun University, Fengcheng, China
  • 2 The First People's Hospital of Xiushui, Jiujiang, Jiangxi, China, Jiangxi, China
  • 3 Gannan Medical University, Ganzhou, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Urological tumors are an important disease affecting global human health, and their pathogenesis and treatment have been the focus of medical research. With the indepth study of microbiomics, the role of the microbiome in urological tumors has gradually attracted attention.However, the current research on tumorassociated microorganisms mostly focuses on one type or one site, and currently, there is a lack of attention to the microbiome in the immunity and immunotherapy of urological tumors. Therefore, in this paper, we systematically review the distribution characteristics of the microbiome (including microorganisms in the gut, urine, and tumor tissues) in urologic tumors, the relationship with disease prognosis, and the potential mechanisms of microbial roles in immunotherapy. In particular, we focus on the molecular mechanisms by which the microbiome at different sites influences tumor immunity through multiple "messengers" and pathways. We aim to further deepen the understanding of microbiome mechanisms in urologic tumors, and also point out the direction for the future development of immunotherapy for urologic tumors.

    Keywords: microbiome, Urologic Neoplasms, tumor immunity, Immunotherapy, Inflammation

    Received: 07 Oct 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Zou, Xu, Luo, Chen and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Huanglin Duan, The First People's Hospital of Xiushui, Jiujiang, Jiangxi, China, Jiangxi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.