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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1506962
Immunosuppressants in Dermatology on Vaccine Immunogenicity: A Prospective Cohort Study of Pemphigus Patients in the Pandemic
Provisionally accepted- 1 Keelung Chang Gung Memorial Hospital, Keelung, Taiwan
- 2 Linkou Chang Gung Memorial Hospital, Linkou, Taiwan
Introduction: Both cellular and humoral responses are important for vaccine protection, but recommendations on immunosuppressants in dermatology are largely based on pre-pandemic experiences. This study aimed to investigate the impacts of immunosuppressants on humoral and cellular immunogenicity to COVID-19 vaccinations in pemphigus patients. of fold change [SD]; higher azathioprine dosage = 0.70 [0.61] folds vs. lower azathioprine dosage = 2.11 [1.03] folds; p = 0.044). Conclusion: Except for a subset of patients with unrecovered B-cell deficiency, rituximab infusion with proper scheduling of vaccination preserved better anti-viral T-cell responses and did not lead to hindered antibody responses in pemphigus patients. All pemphigus patients benefited from receiving the third booster regardless of B-cell status.
Keywords: Vaccine immunogenicity, Anti-viral humoral immunity, Anti-viral T-cell response, rituximab, Azathioprine, Pemphigus Vulgaris
Received: 08 Oct 2024; Accepted: 04 Nov 2024.
Copyright: © 2024 Lu, Lee, Chen, Hui, Chang, Lu, Wang and Chung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chuang-Wei Wang, Linkou Chang Gung Memorial Hospital, Linkou, Taiwan
Wen-Hung Chung, Linkou Chang Gung Memorial Hospital, Linkou, Taiwan
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