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REVIEW article

Front. Immunol.
Sec. Mucosal Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1506292
This article is part of the Research Topic Natural Products and Intestinal Mucosal Immunity View all articles

A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals

Provisionally accepted
Jianping Zhou Jianping Zhou 1Yuting Xi Yuting Xi 2*Ting Wu Ting Wu 1*Xiaoyu Zeng Xiaoyu Zeng 1Jun Yuan Jun Yuan 1Lei Peng Lei Peng 1*Hao Fu Hao Fu 1*Ce Zhou Ce Zhou 1*
  • 1 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 2 Zigong Hospital of Traditional Chinese Medicine, Zigong, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Mitochondria are important organelles that regulate cellular energy and biosynthesis, as well as maintain the body's response to environmental stress. Their dynamics and autophagy influence occurrence of cellular function, particularly under stressful conditions. They can generate reactive oxygen species (ROS) which is a major contributor to inflammatory diseases such as ulcerative colitis (UC). In this review, we discuss the key effects of mitochondrial dynamics and mitophagy on the pathogenesis of UC, with a particular focus on the cellular energy metabolism, oxidative stress, apoptosis, and immunoinflammatory activities. The therapeutic efficacy of existing drugs and phytochemicals targeting the mitochondrial pathway are discussed to reveal important insights for developing therapeutic strategies for treating UC. In addition, new molecular checkpoints with therapeutic potential are identified. We show that the integration of mitochondrial biology with the clinical aspects of UC may generate ideas for enhancing the clinical management of UC.

    Keywords: uc, mitochondrial dynamics, mitophagy, targeted therapy, nature products

    Received: 04 Oct 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Zhou, Xi, Wu, Zeng, Yuan, Peng, Fu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuting Xi, Zigong Hospital of Traditional Chinese Medicine, Zigong, Sichuan Province, China
    Ting Wu, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
    Lei Peng, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
    Hao Fu, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
    Ce Zhou, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.