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REVIEW article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1505755
This article is part of the Research Topic Spatial Transcriptome and Single-Cell Sequencing for Exploring Molecular Mechanisms of Neuroimmunity and Discovering Novel Markers of Neurological Diseases View all 5 articles

Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells

Provisionally accepted
Jian Li Jian Li 1Xiaolei Zhai Xiaolei Zhai 2*Chaochun Yu Chaochun Yu 1,3*
  • 1 Shanghai TCM Integrated Hospital, Shanghai University of TCM, Shanghai, China
  • 2 Shuyang Hospital of Traditional Chinese Medicine•Affiliated Shuyang Hospital of Nanjing University of Chinese Medicine, Shuyang, China
  • 3 Shuyang Hospital of Traditional Chinese Medicine, Shuyang, China

The final, formatted version of the article will be published soon.

    An external trauma, illness, or other pathological cause can harm the structure and function of the spinal cord, resulting in a significant neurological disorder known as spinal cord injury (SCI). In addition to impairing movement and sensory functions, spinal cord injury (SCI) triggers complex pathophysiological responses, with the spatial dynamics of immune cells playing a key role. The inflammatory response and subsequent healing processes following SCI are profoundly influenced by the spatial distribution and movement of immune cells. Despite significant advances in both scientific and clinical research, SCI therapy still faces several challenges. These challenges primarily stem from our limited understanding of the spatial dynamics of immune cell distribution and the processes that regulate their interactions within the microenvironment following injury. Therefore, a comprehensive investigation into the spatial dynamics of immune cells following SCI is essential to uncover their mechanisms in neuroinflammation and repair, and to develop novel therapeutic strategies.

    Keywords: spinal cord injury, Pathology, neuroimmune cells, progression, spatial distribution, immune cells, Inflammatory Response, Immunomodulation

    Received: 03 Oct 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Li, Zhai and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaolei Zhai, Shuyang Hospital of Traditional Chinese Medicine•Affiliated Shuyang Hospital of Nanjing University of Chinese Medicine, Shuyang, China
    Chaochun Yu, Shuyang Hospital of Traditional Chinese Medicine, Shuyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.