Jingxiu Xuan ^* Chaoqiong Deng Huiqin Lu Yan He Jimin Zhang Xiaoli Zeng Yuechi Sun Shiju Chen ^* Yuan Liu ^*

• First Affiliated Hospital of Xiamen University, Xiamen, China

Background: Dyslipidemia presents in various autoimmune diseases, and the serum lipid profile in SLE has not yet been clearly defined. This study aims to evaluate the level of serum lipids in patients with SLE.A case-control study evaluated four conventional sera lipids TC, TG, HDL, and LDL in patients with SLE compared to HCs. Correlations between serum lipids and clinical characteristics were analyzed in patients with SLE. A systematic review and meta-analysis were conducted to assess the epidemiology of lipid profiles in patients with SLE, and a random-effects meta-analysis was performed for data synthesis.Results: TC and TG were elevated significantly, and HDL decreased in patients with SLE compared to HCs. Elevated lipids were associated with progressive disease activity. The TC, TG, and HDL were elevated in patients with SLE and were associated with decreased IgG, increased 24-hour proteinuria, WBC, and neutrophils. Decreased HDL and increased TG were associated with an increase in SLEDAI. Patients with SLE who took GCs may have experienced increases in TC and TG, while those who took HCQ may have experienced increases in TC and HDL. Eleven eligible studies including the present study on associations between serum lipids and SLE were reviewed by the meta-analysis. The results demonstrated elevated TC (MD = 0.85, 95%CI 0.82 to 0.89, P < 0.00001) and TG (MD = 0.96, 95%CI 0.94 to 0.99, P < 0.00001) levels in SLE, while HDL decreased (MD = -0.19, 95%CI -0.20 to -0.17, P < 0.00001).Conclusions: Dyslipidemia is present in SLE. There was a significant association between SLE disease activity and TC, TG, and HDL. The exact pathogenesis of metabolic disorders in SLE needs to be further addressed.