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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1500478
This article is part of the Research Topic Harnessing Molecular Insights for Enhanced Drug Sensitivity and Immunotherapy in Cancer View all 4 articles

PCDHGA10 as a potential prognostic biomarker and correlated with immune infiltration in gastric cancer

Provisionally accepted
Mingyang Zhong Mingyang Zhong Zhuoqun Yu Zhuoqun Yu Qianqian Wu Qianqian Wu Bing Lu Bing Lu Pingping Sun Pingping Sun Xiaojing Zhang Xiaojing Zhang Lei Yang Lei Yang *Han Wu Han Wu *
  • Affiliated Hospital of Nantong University, Nantong, China

The final, formatted version of the article will be published soon.

    Background: Gastric cancer (GC) is one of the most common malignant tumors and is associated with poor prognosis. To improve the prognosis of GC patients, an effective immune-related prognostic biomarker is urgent. Here, we aim to explore the correlation between the expression of procalcitonin gamma subfamily A, 10 (PCDHGA10) and clinicopathological characteristics, especially its relation with tumor-infiltrating immune cells (TILs) in GC.The differential mRNA expression of PCDHGA10 between GC tissues and normal gastric mucosa and prognostic potential were assessed from The Cancer Genome Atlas (TCGA). Then, based on tissue microarrays (TMAs) with multiplex immunohistochemistry (mIHC) from GC patients, we statistically assess the correlation between PCDHGA10 protein expression and the clinical profiles and prognosis of the patients. Additionally, with IHC and mIHC, we applied the machine-learning algorithms to evaluate the localization and expression levels of TILs and immune checkpoints in the tumor microenvironment and. We analyzed the relationship between PCDHGA10 protein expression and TILs and immune checkpoints, respectively.Results: Through the database and TMAs analysis, the expression of PCDHGA10 was significantly higher in GC tissues compared with normal tissues. High PCDHGA10 expression independently predicted poor prognosis in GC. Additionally, elevated 3 PCDHGA10 expression was positively associated with the number of CD8 + T cells, CD68 + macrophages, Foxp3 + T cells, and CD4 + T cells in GC tissues and the stromal region. Besides, the expression of PCDHGA10 was positively correlated with immune checkpoints, including CTLA-4, LAG3, and PD-L1.Conclusions: PCDHGA10 might be a potential prognostic marker and an immunological therapeutic target for GC.

    Keywords: PCDHGA10, multiplex immunohistochemistry, Immunotherapy, prognosis, gastric cancer, Tumor Microenvironment

    Received: 23 Sep 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Zhong, Yu, Wu, Lu, Sun, Zhang, Yang and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lei Yang, Affiliated Hospital of Nantong University, Nantong, China
    Han Wu, Affiliated Hospital of Nantong University, Nantong, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.