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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1500231
This article is part of the Research Topic Cytokine Network Dynamics: Influence on Autoimmune Disorders and Cancer Therapy View all articles

Cytokine Profiling Reveals HLA-linked Th2 and Th17 Driven Immune Activation in Pemphigus Vulgaris Patients and Genetically Susceptible Healthy Controls

Provisionally accepted
Rebekah R Schwartz Rebekah R Schwartz Kristina Seiffert-Sinha Kristina Seiffert-Sinha Animesh A Sinha Animesh A Sinha *
  • Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, United States

The final, formatted version of the article will be published soon.

    Cytokines and chemokines direct the inflammatory response and may serve as markers of immune dysregulation in Pemphigus vulgaris (PV), an autoimmune blistering skin disorder. Previous studies on limited numbers of patients and cytokine profiles in PV have produced equivocal results regarding the role these mediators play in disease. In this study, we interrogated serum samples from 116 PV patients and 29 healthy controls by multiplexed bead array assays across a comprehensive set of cytokines and chemokines covering several functional categories,

    Keywords: Pemphigus, HLA, cytokine, Autoimmunity, Th17, th2

    Received: 23 Sep 2024; Accepted: 08 Nov 2024.

    Copyright: © 2024 Schwartz, Seiffert-Sinha and Sinha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Animesh A Sinha, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, United States

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