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REVIEW article

Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1500228

TIM Proteins and MicroRNAs: Distinct Impact and Promising Interactions on Transplantation Immunity

Provisionally accepted
Jialing Tao Jialing Tao 1Xiaoxuan Shen Xiaoxuan Shen 1Haiqing Qian Haiqing Qian 1Qing Ding Qing Ding 2*Lihong Wang Lihong Wang 1*
  • 1 Zhangjiagang Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Zhangjiagang, China
  • 2 Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

The final, formatted version of the article will be published soon.

    Achieving sustained activity and tolerance inof allogeneic grafts after post-transplantation remains a substantial challenge. The response of the immune system to "non-self" MHC-antigenic peptides initiates a crucial phase, wherein blocking positive co-stimulatory signals becomes imperative to ensure graft survival and tolerance. MicroRNAs (miRNAs) inhibit mRNA translation or promote mRNA degradation by complementary binding of mRNA seed sequences, which ultimately affects protein synthesis. These miRNAs exhibit substantial promise as diagnostic, prognostic, and therapeutic candidates forwithin the realm of solid organ transplantations. Current research has highlighted three members of the T cell immunoglobulin and mucin domain (TIM) family as a novel therapeutic avenue in transplantation medicine and alloimmunization. The interplay between miRNAs and TIM proteins has been extensively explored in viral infections, inflammatory responses, and post-transplantation ischemia-reperfusion injuryies. This review aims to elucidate the distinct roles of miRNAs and TIM in transplantation immunity and delineate their interdependent relationships in terms of targeted regulation. Specifically, this investigation soughtseeks to uncover the potential of miRNA interaction with TIM, aiming to induce immune tolerance and bolster allograft survival after transplantation. This innovative strategy holds substantial promise infor the future of transplantation science and practice.

    Keywords: T cell immunoglobulin and mucin domain, MicroRNAs, Transplantation, allograft rejection, Allograft tolerance

    Received: 23 Sep 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Tao, Shen, Qian, Ding and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qing Ding, Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA 15261, Pennsylvania, United States
    Lihong Wang, Zhangjiagang Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Zhangjiagang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.