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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1498272
This article is part of the Research Topic Immunotherapeutic Advances in Brain Tumors View all articles

Maternal immunization impairs lymphoma Growth and CNS/Ocular metastasis in the offspring

Provisionally accepted
Ori Braitbard Ori Braitbard 1,2Allan Bar-Sinai Allan Bar-Sinai 2Jacob Hochman Jacob Hochman 2*
  • 1 The Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Jerusalem, Israel
  • 2 Hebrew University of Jerusalem, Jerusalem, Israel

The final, formatted version of the article will be published soon.

    Maternal immunization is an important tool directed against a variety of infectious maladies in the offspring. A complementary, but less explored area is the use of maternal immunization in the prevention and treatment of childhood cancers. This in part stems from the lack of adequate experimental model systems. Lymphomas of the Central Nervous System (CNS) and ocular involvement pose a therapeutic challenge. Ocular lymphoma is a lethal disease caused mainly by two clinically distinct forms of non-Hodgkin's lymphoma: non-Hodgkin's lymphoma of the central nervous system, or Primary CNS lymphoma (PCNSL), and systemic lymphoma metastatic to the eye. Previously, we developed an experimental model whereby mouse lymphoma cell variants, derived from the S49 T-cell lymphoma, metastasized to the CNS and eyes following Intraperitoneal inoculation at days 7-10 postnatal Here, we extended the model to study whether maternal immunization can impede CNS/Ocular metastasis in the offspring exposed to the metastatic lymphoma cells. To that effect, female Balb/C mice were vaccinated with either immunogenic, live, S49 lymphoma cell variants, or with a purified protein antigen: the 98 amino acid signal peptide of the envelop precursor protein of Mouse Mammary Tumor Virus (MMTV) endogenously harbored by the S49 lymphoma. The offspring from both vaccination protocols were immunized against a challenge with the CNS/Ocular metastatic lymphoma cells. Immunity was conferred via milk suckling and was prolonged without further challenge for an extended period of at least 3 months. The abovementioned findings constitute a novel experimental model system whereby CNS/Ocular metastasis of malignant lymphoma in the offspring is impeded through maternal vaccination/immunization and thus, can be followed mechanistically as well as for novel therapeutic modalities.

    Keywords: MMTV, MMTV p14, Brain metastase, t cell lymphoma, maternal immunization, CNS/Ocular metastasis

    Received: 18 Sep 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Braitbard, Bar-Sinai and Hochman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jacob Hochman, Hebrew University of Jerusalem, Jerusalem, Israel

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