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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1497788
This article is part of the Research Topic The Liver's Dilemma: Sensing Real Danger in a Sea of PAMPs View all 3 articles

Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance Short Title: LSEC regulate hepatic T cell function

Provisionally accepted
Kimberly Kremer Kimberly Kremer 1Hadeel Khammash Hadeel Khammash 1Anjelica Miranda Anjelica Miranda 1Lauren Rutt Lauren Rutt 2Shannon Twardy Shannon Twardy 2Paige Anton Paige Anton 2Margaret Campbell Margaret Campbell 1Christian Garza-Ortiz Christian Garza-Ortiz 1David Orlicky David Orlicky 3Roberta Pelanda Roberta Pelanda 1Rebecca L McCullough Rebecca L McCullough 2Raul M Torres Raul M Torres 1*
  • 1 Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
  • 2 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
  • 3 School of Medicine, University of Colorado Anschutz Medical Campus, Department of Pathology, Aurora, United States

The final, formatted version of the article will be published soon.

    Abbreviations: CCl4 (carbon tetrachloride), CEA (carcinoembryonic antigen), CFSE (carboxyfluorescein succinimidyl ester), CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), CTV (cell trace violet), DC (dendritic cell), DEN (diethylnitrosamine), HCC (hepatocellular carcinoma), ICAM-1 (intercellular adhesion molecule-1), IFN (interferon-), IL-10 (interleukin 10), IL-2 (interleukin 2), IM (infiltrating macrophages), KC (Kupffer cells), Lag3 (lymphocyte activation gene 3), LCMV (lymphocytic choriomeningitis virus), LSEC (liver sinusoidal endothelial cells), MHC I (major histocompatibility complex I), MHC II (major histocompatibility complex II), N4 (SIINFEKL), NPC (nonparenchymal cells), OVA (ovalbumin), PD-1 (programmed cell death protein 1), PD-L1 (programmed cell death ligand 1), PDPN (podoplanin), TGF- (transforming growth factor-), TIGIT (T cell immunoglobulin and ITIM domain), Tim3 (T cell immunoglobulin and mucin-domain containing-3), TNF (tumor necrosis factor), Treg (T regulatory cell).

    Keywords: Liver sinusoidal endothelial cells, t cell exhaustion, Hepatocellular Carcinoma, T cell, Immunosuppression

    Received: 17 Sep 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Kremer, Khammash, Miranda, Rutt, Twardy, Anton, Campbell, Garza-Ortiz, Orlicky, Pelanda, McCullough and Torres. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Raul M Torres, Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, 80045, Colorado, United States

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