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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Nutritional Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1497068
This article is part of the Research Topic Nutrition, Inflammation and Immunity in Liver and Gastrointestinal Disorders View all articles

Association between complete blood cell count-derived inflammatory biomarkers and gallstones prevalence in American adults under 60 years of age

Provisionally accepted
Chang Fu Chang Fu 1Xiaocong Li Xiaocong Li 2Yongxin Wang Yongxin Wang 1Junhong Chen Junhong Chen 1Yibo Yang Yibo Yang 1Kai Liu Kai Liu 1*
  • 1 Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China
  • 2 China-Japan Friendship Hospital, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: The trend of gallstones occurring in younger populations has become a noteworthy public health issue. This study aims to investigate the association between complete blood cell count (CBC)-derived inflammatory indicators and gallstones in adults under 60 years of age in the United States. Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020.Associations between CBC-derived inflammatory biomarkers and gallstones were assessed using multivariable logistic regression models, with results presented as odds ratio (OR) and 95% confidence interval (CI).Restricted cubic splines (RCS) were employed to examine potential nonlinear relationships. Subgroup analyses were also conducted to explore differences across population subgroups.: This study comprised 4,977 participants, among whom 398 were diagnosed with gallstones. After adjusting for confounding variables, the highest quartile of systemic inflammation response index (SIRI) [OR (95%CI): 1.65(1.12,2.43)], systemic immune-inflammation index (SII) [OR (95%CI): 1.53(1.05,2.25)], monocyte-to-lymphocyte ratio (MLR) [OR (95%CI): 1.66(1.16,2.37)], and pan immune inflammatory value (PIV) [OR (95%CI): 1.82(1.23,2.71)] were associated with a significantly increased risk of gallstones compared to the lowest quartiles. RCS plots indicated a nonlinear relationship between several inflammatory biomarkers and gallstones. Conclusion: Our study found that SIRI, SII, MLR, and PIV can serve as clinical indicators for predicting the risk of gallstones in adults under 60 years of age in the United States.

    Keywords: CBC-derived inflammatory indicators, Gallstones, NHANES, Cholelithiasis, Inflammation

    Received: 16 Sep 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Fu, Li, Wang, Chen, Yang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kai Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.