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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1494570

The Role of Aryl Hydrocarbon Receptor in the occurrence and development of periodontitis

Provisionally accepted
Lingzhi Wu Lingzhi Wu 1,2,3Xiting Li Xiting Li 1,2,3Jinyu Li Jinyu Li 1,2,3*Yan Wang Yan Wang 1,2,3Canyu Yang Canyu Yang 1,2,3*Chuanjiang Zhao Chuanjiang Zhao 1,2,3*Li Gao Li Gao 1,2,3*
  • 1 Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China
  • 2 Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China
  • 3 Hospital of Stomatology, Sun Yat-sen University, Guangdong, China

The final, formatted version of the article will be published soon.

    Periodontitis is a condition characterized by dysbiosis of microbiota and compromised host immunological responses, resulting in the degradation of periodontal tissues. The aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, plays a crucial role in the pathogenesis of periodontitis. AHR serves as a pivotal mediator for the adverse impacts of exogenous pollutants on oral health. Research indicates elevated expression of AHR in individuals with periodontitis compared to those without the condition. However, subsequent to the identification of endogenous AHR ligands, researches have elucidated numerous significant advantageous roles associated with AHR activation in bone, immune, and epithelial cells. This review concentrates on the modulation of the AHR pathway and the intricate functions that AHR plays in periodontitis. It discusses the characteristics of AHR ligands, detailing the established physiological functions in maintaining alveolar bone equilibrium, regulating immunity, facilitating interactions between the oral microbiome and host, and providing protection to epithelial tissues, while also exploring its potential roles in systemic disorders related to periodontitis.

    Keywords: AhR, Periodontitis, tryptophan metabolism, Alveolar bone homeostasis, Oral Microbiome-host Interactions

    Received: 11 Sep 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Wu, Li, Li, Wang, Yang, Zhao and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jinyu Li, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510275, China
    Canyu Yang, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510275, China
    Chuanjiang Zhao, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510275, China
    Li Gao, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510275, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.