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CASE REPORT article

Front. Immunol.
Sec. Microbial Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1494168

A Rare Case of Leclercia adecarboxylata Bacteremia in an Immunocompetent Psychiatric Patient: Exploring the Links Between Mental Health and Infectious Diseases

Provisionally accepted
Fei Yan Fei Yan 1,2Xi Ruan Xi Ruan 1,2*Qin Tang Qin Tang 1,2*Guo Lin Song Guo Lin Song 1,2*Ren Fang Xie Ren Fang Xie 1,2*Xing Chen Bao Xing Chen Bao 3*
  • 1 Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
  • 2 Chengdu Fourth People's Hospital, Chengdu, Sichuan Province, China
  • 3 Panzhihua Central Hospital, Panzhihua, China

The final, formatted version of the article will be published soon.

    This study aims to explore the pathogenic potential of Leclercia adecarboxylata as a rare pathogen in immunocompetent individuals and to analyze how mental health status may influence susceptibility to infection. We report a case of bacteremia in a 31-year-old immunocompetent female who developed L. adecarboxylata infection during an episode of severe depression. Although the patient exhibited self-harm tendencies, a thorough physical examination did not reveal any external wounds or signs of injury. This case demonstrates that, despite the absence of obvious external infection sources, invasive procedures, or visible trauma, L. adecarboxylata can induce severe bacteremia in immunocompetent individuals. The patient presented with high fever and systemic inflammatory response, with blood cultures confirming the presence of L. adecarboxylata, and chest imaging showing bilateral lower lobe inflammation. Following treatment with ceftriaxone, the patient's symptoms rapidly improved, and infection markers normalized. This study elucidates the potential mechanisms by which L. adecarboxylata can cause infection in immunocompetent individuals and examines the influence of mental health on infection susceptibility. It provides new insights into the complex relationship between mental illness and infection, highlighting the need for further investigation into how mental health may affect infection risk and its clinical management. In conjunction with existing research, this study discusses how psychological stress and behavioral patterns may increase infection risk and recommends future research to further explore the interplay between mental disorders and infectious diseases.

    Keywords: Leclercia adecarboxylata1, Immunocompetent Host2, Bacteremia3, Mental Health and Infection4, Emerging Pathogen5. (Min

    Received: 10 Sep 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Yan, Ruan, Tang, Song, Xie and Bao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xi Ruan, Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, 610054, Sichuan Province, China
    Qin Tang, Chengdu Fourth People's Hospital, Chengdu, Sichuan Province, China
    Guo Lin Song, Chengdu Fourth People's Hospital, Chengdu, Sichuan Province, China
    Ren Fang Xie, Chengdu Fourth People's Hospital, Chengdu, Sichuan Province, China
    Xing Chen Bao, Panzhihua Central Hospital, Panzhihua, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.