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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1494155
This article is part of the Research Topic Investigating Splicing Event as Therapeutic Targets in Inflammatory disease View all articles

Immune regulation: a new strategy for traditional Chinese medicine-based treatment of granulomatous lobular mastitis

Provisionally accepted
Yuan Lou Yuan Lou 1Han Xu Han Xu 1Zixuan Lu Zixuan Lu 2Xiaofei Liu Xiaofei Liu 3*Bin Wang Bin Wang 2*
  • 1 First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
  • 2 Department of Immunology, School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong Province, China
  • 3 Department of Breast and Thyroid Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Granulomatous lobular mastitis (GLM) presents significant challenges, including high rates of morbidity, recurrence, and disability, ultimately impacting women's health and quality of life. Local autoimmune imbalance involving dysregulated cytokines and immune cells has been recognized to play a key role in the pathology of GLM.Traditional Chinese medicine (TCM), with its multi-component, multi-pathway and multi-target characteristics, offers unique advantages and broad prospects in the treatment of GLM. Here, we review the relationship between immune dysregulation and GLM, as well as the regulatory mechanisms of TCM-based interventions, with the aim of providing new insights and foundational knowledge for the clinical treatment of GLM, while promoting the further application and development of TCMbased strategies for the treatment of GLM.

    Keywords: Granulomatous lobular mastitis, Autoimmunity, Pathogenesis, Traditional Chinese Medicine, pyroptosis, crosstalk

    Received: 10 Sep 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Lou, Xu, Lu, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaofei Liu, Department of Breast and Thyroid Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China
    Bin Wang, Department of Immunology, School of Basic Medical Sciences, Binzhou Medical University, Yantai, 264003, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.