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REVIEW article

Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1491729
This article is part of the Research Topic IUIS Junior Community: Pushing the Frontiers of Immunology View all articles

Hematopoietic stem cell a reservoir of innate immune memory

Provisionally accepted
Lucas Ruffinatto Lucas Ruffinatto Yann Groult Yann Groult Johanna Iacono Johanna Iacono Sandrine Sarrazin Sandrine Sarrazin Berengere De Laval Berengere De Laval *
  • INSERM U1104 Centre d'immunologie de Marseille-Luminy (CIML), Marseille, Provence-Alpes-Côte d'Azur, France

The final, formatted version of the article will be published soon.

    Hematopoietic stem cells (HSCs) are a rare, long-lived and multipotent population that give rise to majority of blood cells and some tissue-resident immune cells. There is growing evidence that inflammatory stimuli can trigger persistent reprogramming in HSCs that enhances or inhibits the cellular functions of these HSCs and their progeny in response to subsequent infections. This newly discovered property makes HSCs a reservoir for innate immune memory. The molecular mechanisms underlying innate immune memory in HSCs are similar to those observed in innate immune cells, although their full elucidation is still pending. In this review, we examine the current state of knowledge on how an inflammatory response leads to reprogramming of HSCs. Understanding the full spectrum of consequences of reshaping early hematopoiesis is critical for assessing the potential benefits and risks under physiological and pathological conditions.

    Keywords: hematopoietic stem & progenitor cells (HSPCs), Innate immune memory, Inflammation, epigenetic, Emergency hematopoiesis, Metobolism, Myelopoeisis

    Received: 05 Sep 2024; Accepted: 30 Oct 2024.

    Copyright: © 2024 Ruffinatto, Groult, Iacono, Sarrazin and De Laval. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Berengere De Laval, INSERM U1104 Centre d'immunologie de Marseille-Luminy (CIML), Marseille, 13288, Provence-Alpes-Côte d'Azur, France

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