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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1490478
This article is part of the Research Topic Pattern Recognition Receptors: Balancing Inflammation and Immune Homeostasis View all articles

TLR10 overexpression modulates immune response in A549 lung epithelial cells challenged with SARS-CoV-2 S and N proteins

Provisionally accepted
Špela Knez Špela Knez Mojca Narat Mojca Narat Jernej Ogorevc Jernej Ogorevc *
  • Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia

The final, formatted version of the article will be published soon.

    Toll-like receptors (TLRs) play an important role in the recognition of viral particles and activation of the innate immune system, but their role in SARS-CoV-2 infection is still poorly characterized. In the present study, we investigated the role of Toll-like receptor 10 (TLR10) in modulating the immune response during SARS-CoV-2 infection. The results showed that overexpression of TLR10 in A549 lung epithelial cells, immunostimulated with SARS-CoV-2 proteins S and N mainly downregulated proinflammatory cytokines and interferons and affected gene expression in the cocultured THP-1 monocytes. Our results suggest that TLR10 could mediate the extent of SARS-CoV-2 infection by downregulating the release of inflammatory cytokines and chemokines such as CXCL10, IL6, IL8, and IFNβ. Modulation of TLR10 expression could have implications for the treatment of patients with severe COVID-19, in whom excessive inflammation leading to the development of acute respiratory distress syndrome (ARDS) is a key feature. However, further research is needed to fully understand the impact of modulating TLR10 expression on the antiviral response and the overall balance of the immune response during SARS-CoV-2 infection.

    Keywords: SARS-CoV-21, Covid-192, Toll-like receptor 103, Interferons4, Proinflammatory cytokines5, innate immunity6

    Received: 03 Sep 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Knez, Narat and Ogorevc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jernej Ogorevc, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia

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