Jing Wang
1
Lan Ma
2*The final, formatted version of the article will be published soon.
REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1490395
Factors Influencing Glycocalyx Degradation: A Narrative Review
Provisionally accepted- 1 Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi Zhuang Region, China
- 2 Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou, Zhejiang Province, China
The glycocalyx is a layer of villus-like structure covering the luminal surface of vascular endothelial cells. Damage to the glycocalyx has been proven linked to the development of many diseases. However, the factors that promote damage to the glycocalyx are not fully elaborated. This review summarizes factors leading to the reduction of the glycocalyx in detail, including inflammatory factors, ischemia-reperfusion, oxidative stress, lipids, glucose, high sodium, female sex hormones and others. Additionally, the mechanisms underlying its degradation are discussed. To better prevent and treat related diseases induced by glycocalyx degradation, it is a meaningful measure to avoid these factors.
Keywords: Cell Membrane Structures, Endothelium, Inflammation, review, Glycocalyx
Received: 03 Sep 2024; Accepted: 30 Dec 2024.
Copyright: © 2024 Wang, Ma, Fang, Ye, Li and Lan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lan Ma, Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou, Zhejiang Province, China
Yu Fang, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi Zhuang Region, China
Teng teng Ye, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi Zhuang Region, China
Bo hong Li, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi Zhuang Region, China
Peng Lan, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi Zhuang Region, China
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