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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1489444
This article is part of the Research Topic Formation of Immunological Niches in Tumor Microenvironments: Mechanisms and Therapeutic Potential View all 6 articles
Single-Cell Sequencing Unveils Mitophagy-Related Prognostic Model for Triple-Negative Breast Cancer
Provisionally accepted- 1 National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China
- 2 Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing Municipality, China
- 3 Department of Nutrition, School of Public Health, Harvard University, Boston, Massachusetts, United States
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking hormone receptors and HER2 expression, leading to limited treatment options and poor prognosis. Mitophagy, a selective autophagy process targeting damaged mitochondria, plays a complex role in cancer progression, yet its prognostic significance in TNBC is not well understood.This study utilized single-cell RNA sequencing data from the TCGA and GEO databases to identify mitophagy-related genes (MRGs) associated with TNBC. A prognostic model was developed using univariate Cox analysis and LASSO regression. The model was validated across multiple independent cohorts, and correlations between MRG expression, immune infiltration, and drug sensitivity were explored.Nine key MRGs were identified and used to stratify TNBC patients into high-risk and low-risk groups, with the high-risk group showing significantly worse survival outcomes. The model demonstrated strong predictive accuracy across various datasets. Additionally, the study revealed a correlation between higher MRG expression levels and increased immune cell infiltration, as well as potential responsiveness to specific chemotherapeutic agents.The mitophagy-related prognostic model offers a novel method for predicting outcomes in TNBC patients and highlights the role of mitophagy in influencing the tumor microenvironment, with potential applications in personalized treatment strategies.
Keywords: : Triple-negative breast cancer, mitophagy, single-cell sequencing, Prognostic model, Immunoassay
Received: 01 Sep 2024; Accepted: 11 Oct 2024.
Copyright: © 2024 丁, Shengbin, Qu, Yang, Liu, Kong, Wang, Wang and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yazhe Yang, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, 100006, Beijing Municipality, China
Qiang Liu, Department of Nutrition, School of Public Health, Harvard University, Boston, Massachusetts, United States
Xiangyi Kong, National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China
Zhongzhao Wang, National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China
Yi Fang, National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China
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