Skip to main content

REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1489378
This article is part of the Research Topic Molecular Pathways and Signaling Molecules in Cancer Therapy: Advances and Innovations View all articles

circFOXP1: A potential diagnostic and therapeutic target in human diseases

Provisionally accepted
Qiang Yi Qiang Yi 1Xinting Ouyang Xinting Ouyang 1Kui Zhong Kui Zhong 1Zheng Chen Zheng Chen 1WeiJian Zhu WeiJian Zhu 1Gangfeng Zhu Gangfeng Zhu 1Jinghua Zhong Jinghua Zhong 2*
  • 1 Gannan Medical University, Ganzhou, Jiangxi Province, China
  • 2 First Affiliated Hospital of Gannan Medical University, Ganzhou, China

The final, formatted version of the article will be published soon.

    Circular RNA (circRNA) are a unique class of non-coding RNAs characterized by their covalently closed loop structures, which grant them properties such as stability and conservation. Among these, circFOXP1 has been implicated in various diseases, including cancers, respiratory, skeletal, and cardiovascular disorders. This review systematically examines circFOXP1's role in disease progression, highlighting its involvement in critical biological processes, including cell proliferation, invasion, apoptosis, and autophagy. Mechanistically, circFOXP1 functions through miRNA sponging, protein interactions, and modulation of key signaling pathways such as Wnt and PI3K/AKT. We discuss its potential as a diagnostic and therapeutic target. Our analysis also identifies key unresolved questions, such as the precise regulatory networks involving circFOXP1 and its translation potential, offering pathways for future research.

    Keywords: circRNA, circFOXP1, Molecular mechanisms, biomarker, treatment target

    Received: 01 Sep 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Yi, Ouyang, Zhong, Chen, Zhu, Zhu and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jinghua Zhong, First Affiliated Hospital of Gannan Medical University, Ganzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.