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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1487576

The Role of Inflammatory Response and Metabolic Reprogramming in Sepsis-Associated Acute Kidney Injury: Mechanistic Insights and Therapeutic Potential

Provisionally accepted
An-Bu Liu An-Bu Liu 1*Bin Tan Bin Tan 1*Ping Yang Ping Yang 1*Na Tian Na Tian 1*Jin-Kui Li Jin-Kui Li 1*Si-Cong Wang Si-Cong Wang 2*Lishan Yang Lishan Yang 1Lei Ma Lei Ma 1*Jun-Fei Zhang Jun-Fei Zhang 1*
  • 1 General Hospital of Ningxia Medical University, Yinchuan, China
  • 2 Yanchi County People's Hospital, Yanchi, China

The final, formatted version of the article will be published soon.

    Sepsis represents a severe condition characterized by organ dysfunction resulting from a dysregulated host response to infection. Among the organs affected, the kidneys are particularly vulnerable, with significant functional impairment that markedly elevates mortality rates. Previous researches have highlighted that both inflammatory response dysregulation and metabolic reprogramming are crucial in the onset and progression of sepsis associated acute kidney injury (SA-AKI), making these processes potential targets for innovative therapies. This study aims to elucidate the pathophysiological mechanisms of renal injury in sepsis by perspective of inflammatory response dysregulation, with particular emphasis on pyroptosis, necroptosis, autophagy, and ferroptosis. Furthermore, it will incorporate insights into metabolic reprogramming to provide a detailed analysis of the mechanisms driving SA-AKI and explore potential targeted therapeutic strategies, providing solid theoretical framework for the development of targeted therapies for SA-AKI.

    Keywords: sepsis associated acute kidney injury (SA-AKI), Inflammatory Response, metabolic reprogramming, regulatory cell death (RCD), Mechanism

    Received: 28 Aug 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Liu, Tan, Yang, Tian, Li, Wang, Yang, Ma and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    An-Bu Liu, General Hospital of Ningxia Medical University, Yinchuan, China
    Bin Tan, General Hospital of Ningxia Medical University, Yinchuan, China
    Ping Yang, General Hospital of Ningxia Medical University, Yinchuan, China
    Na Tian, General Hospital of Ningxia Medical University, Yinchuan, China
    Jin-Kui Li, General Hospital of Ningxia Medical University, Yinchuan, China
    Si-Cong Wang, Yanchi County People's Hospital, Yanchi, China
    Lei Ma, General Hospital of Ningxia Medical University, Yinchuan, China
    Jun-Fei Zhang, General Hospital of Ningxia Medical University, Yinchuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.