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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1486627
This article is part of the Research Topic Paradoxical Reaction through Immune-related Dermatoses: Mechanism and Treatment Strategy View all 3 articles

Mechanisms of Autophagy and Their Implications in Dermatological Disorders

Provisionally accepted
Shenghao Xue Shenghao Xue 1Yumeng Lin Yumeng Lin 2Haoran Chen Haoran Chen 3Zhengyu Yang Zhengyu Yang 4Junting Zha Junting Zha 2Xuan Jiang Xuan Jiang 4Zhongyu Han Zhongyu Han 3*Ke Wang Ke Wang 4
  • 1 Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • 2 Naniing Tongren Hospital, School of Medicine, Southeast University, Nanjing, Liaoning Province, China
  • 3 Affiliated Chengdu Xinhua hospital of north Sichuan medical college, Chengdu, Sichuan Province, China
  • 4 Hospital of Chengdu University of Traditional Chinese Medicine Deyang Hospital, Deyang, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Autophagy is a highly conserved cellular self-digestive process that underlies the maintenance of cellular homeostasis. Autophagy is classified into three types: macrophage, chaperone-mediated autophagy (CMA) and microphagy, which maintain cellular homeostasis through different mechanisms. Altered autophagy regulation affects the progression of various skin diseases, including psoriasis (PA), systemic lupus erythematosus (SLE), vitiligo, atopic dermatitis (AD), alopecia areata (AA) and systemic sclerosis (SSc). In this review, we review the existing literature focusing on three mechanisms of autophagy, namely macrophage, chaperone-mediated autophagy and microphagy, as well as the roles of autophagy in the above six dermatological disorders in order to aid in further studies in the future.

    Keywords: Autophagy, Psoriasis, systemic lupus erythematosus, Vitiligo, atopic dermatitis, Pemphigus, systemic sclerosis

    Received: 26 Aug 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Xue, Lin, Chen, Yang, Zha, Jiang, Han and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhongyu Han, Affiliated Chengdu Xinhua hospital of north Sichuan medical college, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.