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REVIEW article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1486476
This article is part of the Research Topic Community Series in Recent Advances in Potential Biomarkers for Rheumatic Diseases and in Cell-based Therapies in the Management of Inflammatory Rheumatic Diseases: Volume III View all articles

Noncoding RNAs in Rheumatoid Arthritis: Modulators of the NF-κB Signaling Pathway and Therapeutic Implications

Provisionally accepted
Zohreh Rezaei Zohreh Rezaei 1*Dina Seyedi Dina Seyedi 2Najmadin Espandar Najmadin Espandar 3Maryam Hojatizadeh Maryam Hojatizadeh 2Yaser Mohammadi Yaser Mohammadi 4Farzad Sadri Farzad Sadri 5
  • 1 University of Sistan and Baluchestan, Zahedan, Iran
  • 2 Tehran University of Medical Sciences, Tehran, Tehran, Iran
  • 3 Urmia University, Urmia, West Azerbaijan, Iran
  • 4 Iran University of Medical Sciences, Tehran, Tehran, Iran
  • 5 Birjand University of Medical Sciences, Birjand, South Khorasan, Iran

The final, formatted version of the article will be published soon.

    Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint inflammation and gradual tissue destruction. New research has shown how important noncoding RNAs (ncRNAs) are for changing immune and inflammatory pathways, such as the WNT signaling pathway, which is important for activating synovial fibroblasts and osteoblasts to work. This article examines the current understanding of several ncRNAs, such as miRNAs, lncRNAs, and circRNAs, that influence NF-κB signaling in the pathogenesis of RA. We investigate how these ncRNAs impact NF-κB signaling components, altering cell proliferation, differentiation, and death in joint tissues.The paper also looks at how ncRNAs can be used as potential early detection markers and therapeutic targets in RA because they can change important pathogenic pathways. This study highlights the therapeutic potential of targeting ncRNAs in RA therapy techniques, with the goal of reducing inflammation and stopping disease progression. This thorough analysis opens up new possibilities for understanding the molecular foundations of RA and designing novel ncRNA-based treatments.

    Keywords: noncoding RNAs, NF-κB signaling pathway, Rheumatoid arthritis, therapeutic targets, Synovial fibroblasts Font color: Auto, Highlight Font color: Auto, Highlight Formatted: Highlight Formatted: Font color: Auto, Highlight Font: 12 pt

    Received: 26 Aug 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Rezaei, Seyedi, Espandar, Hojatizadeh, Mohammadi and Sadri. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zohreh Rezaei, University of Sistan and Baluchestan, Zahedan, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.