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CASE REPORT article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1486214
This article is part of the Research Topic Emerging Paradigms in Understanding Cancer Metastasis: Focus on Tumor Microenvironment Dynamics View all 3 articles

Lung enteric-type adenocarcinoma with gastric metastasis: A rare case report and literature review

Provisionally accepted
Xiaoning Li Xiaoning Li 1Kewei Ma Kewei Ma 1Xiaobo Ma Xiaobo Ma 2Xiangye Zhao Xiangye Zhao 1Mengge Fan Mengge Fan 1Yinghui Xu Yinghui Xu 1*
  • 1 Cancer Center, The First Hospital of Jilin University, Changchun, China
  • 2 Department of Pathology, First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Lung enteric-type adenocarcinoma (ETAC) is a rare subtype of non-small cell lung cancer (NSCLC), comprising approximately 0.6% of all primary lung adenocarcinomas. It is characterized by a tendency for early metastasis and a prognosis comparable to that of common lung adenocarcinoma. This case report described a patient with lung-ETAC who developed gastric metastasis. The patient underwent treatment with chemotherapy and a PD-1 inhibitor, resulting in disease remission with a progression-free survival (PFS) of 8 months. The follow-up time was 13 months. This case report was aimed to enhance understanding of the biological behavior of this rare tumor and provide insights into potential future treatment strategies.

    Keywords: Lung enteric-type adenocarcinoma, Gastric metastasis, NRAS gene exon 3 mutation, Chemotherapy and Immunotherapy, Non-small cell lung cancer

    Received: 25 Aug 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Li, Ma, Ma, Zhao, Fan and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yinghui Xu, Cancer Center, The First Hospital of Jilin University, Changchun, China

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