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REVIEW article

Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1485905

Donor-Derived Cell-Free DNA: Kidney Transplant Health Biomarker

Provisionally accepted
Wenqiang Zhang Wenqiang Zhang Bin Liu Bin Liu Honglan Zhou Honglan Zhou Dan Jia Dan Jia Ruiyu Wang Ruiyu Wang Lei Wang Lei Wang Tong Yang Tong Yang Tao Xu Tao Xu Baoshan Gao Baoshan Gao *
  • First Affiliated Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    After kidney transplantation, closely monitoring graft function and complications such as rejection is crucial for ensuring successful transplantation and long-term survival. Commonly used plasma creatinine is not specific or sensitive enough to promptly guide histological examinations. Although histological examination is the gold standard, its invasiveness and expensive cost limits its frequent use. In recent years, donor-derived cell-free DNA (dd-cfDNA) has emerged as one of the most promising biomarkers for monitoring solid organ transplants. dd-cfDNA, a non-invasive biomarker found in various types of graft injuries, can monitor graft status through blood and urine analysis, providing more accurate information about the transplant. This paper primarily discusses the role of dd-cfDNA in monitoring kidney transplants to aid clinical practice.

    Keywords: donor-derived cell-free DNA, Kidney Transplantation, Graft injury, rejection, non-invasive monitoring

    Received: 25 Aug 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Zhang, Liu, Zhou, Jia, Wang, Wang, Yang, Xu and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Baoshan Gao, First Affiliated Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.