Skip to main content

REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1485368

CCL20-CCR6 axis in cancer progression: clinical and therapeutic implications

Provisionally accepted
GuanHua Yu GuanHua Yu Tao Fan Tao Fan Yixiao Liu Yixiao Liu Chunxiang Li Chunxiang Li Zheng Jiang Zheng Jiang *Xishan Wang Xishan Wang
  • Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    C-C motif chemokine ligand 20 (CCL20) is widely expressed in various human tissues and immune cells, playing a critical role in immune cell migration and inflammation.As the sole ligand of CCL20, C-C motif chemokine receptor 6 (CCR6) is a G proteincoupled receptor mainly expressed in immune cells and mediates chemotactic function of CCL20. The CCL20-CCR6 axis actively participates in immune homeostasis and activation. Dysregulation of CCL20-CCR6 axis is regarded as an imperative part of the pathogenic mechanism of cancers, and a multitude of therapeutic strategies have been developed to target CCL20-CCR6 axis. In this review, we comprehensively summarized researches of CCL20-CCR6 axis and introduced the biology and functions of CCL20-CCR6 under normal conditions. The pivotal pathogenic roles of CCL20-CCR6 axis in the progression of cancers from multiple directions were further discussed.The article also explored recent advancements in the field of CCL20-CCR6 axis inhibition in cancers, shedding light on its potential as a promising therapeutic target.A systematic understanding of the CCL20-CCR6 axis in the progression of cancers is crucial for realizing the full potential of CCL20-CCR6 axis-based interventions, heralding the promise of improved outcomes for patients.

    Keywords: chemokine, CCL20, CCR6, Cancer, Pathogenesis, Tumor Microenvironment, targeted therapy

    Received: 23 Aug 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Yu, Fan, Liu, Li, Jiang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zheng Jiang, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, 100006, Beijing Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.