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REVIEW article
Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1483740
This article is part of the Research Topic Towards the Rapid and Systematic Assessment of Vaccine Technologies View all articles
Analysis of immunogenicity and purification methods in conjugated polysaccharide vaccines: a new approach in fighting pathogenic bacteria
Provisionally accepted- Zanjan University of Medical Sciences, Zanjān, Iran
Carbohydrates are commonly found in conjunction with lipids or proteins, resulting in the formation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. These glycoconjugates are essential in various biological activities, including inflammation, cell-cell recognition, bacterial infections, and immune response. Nonetheless, the isolation of naturally occurring glycoconjugates presents challenges due to their typically heterogeneous nature, resulting in variations between batches in structure and function, impeding a comprehensive understanding of their mechanisms of action.Consequently, there is a strong need for the efficient synthesis of artificial glycoconjugates with precisely described compositions and consistent biological properties. The chemical and enzymatic approaches discussed in this paper present numerous research opportunities to develop customised glycoconjugate vaccines.
Keywords: glycoconjugate, Vaccine, polysaccharide, Conjugate, Polysaccharide vaccine, Immunogenicity, conjugate vaccine, Antibacterial vaccine
Received: 20 Aug 2024; Accepted: 31 Oct 2024.
Copyright: © 2024 Sheikhi, Shirmohammadpour, Nasirmahalleh and Mirzaei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dr. Bahman Mirzaei, Zanjan University of Medical Sciences, Zanjān, Iran
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