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REVIEW article

Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1483740
This article is part of the Research Topic Towards the Rapid and Systematic Assessment of Vaccine Technologies View all articles

Analysis of immunogenicity and purification methods in conjugated polysaccharide vaccines: a new approach in fighting pathogenic bacteria

Provisionally accepted
Arya Sheikhi Arya Sheikhi Mina Shirmohammadpour Mina Shirmohammadpour Nima M. Nasirmahalleh Nima M. Nasirmahalleh Dr. Bahman Mirzaei Dr. Bahman Mirzaei *
  • Zanjan University of Medical Sciences, Zanjān, Iran

The final, formatted version of the article will be published soon.

    Carbohydrates are commonly found in conjunction with lipids or proteins, resulting in the formation of glycoconjugates such as glycoproteins, glycolipids, and proteoglycans. These glycoconjugates are essential in various biological activities, including inflammation, cell-cell recognition, bacterial infections, and immune response. Nonetheless, the isolation of naturally occurring glycoconjugates presents challenges due to their typically heterogeneous nature, resulting in variations between batches in structure and function, impeding a comprehensive understanding of their mechanisms of action.Consequently, there is a strong need for the efficient synthesis of artificial glycoconjugates with precisely described compositions and consistent biological properties. The chemical and enzymatic approaches discussed in this paper present numerous research opportunities to develop customised glycoconjugate vaccines.

    Keywords: glycoconjugate, Vaccine, polysaccharide, Conjugate, Polysaccharide vaccine, Immunogenicity, conjugate vaccine, Antibacterial vaccine

    Received: 20 Aug 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Sheikhi, Shirmohammadpour, Nasirmahalleh and Mirzaei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dr. Bahman Mirzaei, Zanjan University of Medical Sciences, Zanjān, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.