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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1483400

Lactate's Impact on Immune Cells in Sepsis: Unraveling the Complex Interplay

Provisionally accepted
Tao Zhang Tao Zhang 1Linjian Chen Linjian Chen 1Gatkek Kueth Gatkek Kueth 1Emily Shao Emily Shao 2Xiaohui Wang Xiaohui Wang 1Tuanzhu Ha Tuanzhu Ha 1David L. Williams David L. Williams 1Chuanfu Li Chuanfu Li 1Min Fan Min Fan 1Kun Yang Kun Yang 1*
  • 1 East Tennessee State University, Johnson City, United States
  • 2 Vanderbilt University, Nashville, Tennessee, United States

The final, formatted version of the article will be published soon.

    Lactate significantly impacts immune cell function in sepsis and septic shock, transcending its traditional view as just a metabolic byproduct. This review summarizes the role of lactate as a biomarker and its influence on immune cell dynamics, emphasizing its critical role in modulating immune responses during sepsis.The interaction between lactate and immune cells is central to understanding sepsisassociated immune dysregulation, offering insights that can guide future research and improve therapeutic strategies to enhance patient outcomes.

    Keywords: Sepsis, Lactate, immune cell, immunosuppressiion, Immune responce

    Received: 19 Aug 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Zhang, Chen, Kueth, Shao, Wang, Ha, Williams, Li, Fan and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kun Yang, East Tennessee State University, Johnson City, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.