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REVIEW article

Front. Immunol.
Sec. Microbial Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1482214
This article is part of the Research Topic Epigenetics in the microbiome-host crosstalk: from mechanisms to Therapeutics View all 9 articles

The Gut Homeostasis-Immune System Axis: Novel Insights into Rheumatoid Arthritis Pathogenesis and Treatment

Provisionally accepted
Peng Qi Peng Qi 1Xin Chen Xin Chen 2*Jiexiang Tian Jiexiang Tian 2*Kexin Zhong Kexin Zhong 1Zhonghua Qi Zhonghua Qi 1*Menghan Li Menghan Li 1*Xingwen Xie Xingwen Xie 1,2*
  • 1 Gansu University of Chinese Medicine, Lanzhou, China
  • 2 Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Rheumatoid arthritis is a widely prevalent autoimmune bone disease that imposes a significant burden on global healthcare systems due to its increasing incidence. In recent years, attention has focused on the interaction between gut homeostasis and the immune system, particularly in relation to bone health. Dysbiosis, which refers to an imbalance in the composition and function of the gut microbiota, has been shown to drive immune dysregulation through mechanisms such as the release of pro-inflammatory metabolites, increased gut permeability, and impaired regulatory T cell function. These factors collectively contribute to immune system imbalance, promoting the onset and progression of Rheumatoid arthritis. Dysbiosis induces both local and systemic inflammatory responses, activating key pro-inflammatory cytokines such as tumor necrosis factor-alpha, Interleukin-6, and Interleukin-17, which exacerbate joint inflammation and damage. Investigating the complex interactions between gut homeostasis and immune regulation in the context of Rheumatoid arthritis pathogenesis holds promise for identifying new therapeutic targets, revealing novel mechanisms of disease progression, and offering innovative strategies for clinical treatment.

    Keywords: Gut homeostasis, Immune System, Rheumatoid arthritis, Pathogenesis, novel therapeutic approaches

    Received: 17 Aug 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Qi, Chen, Tian, Zhong, Qi, Li and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xin Chen, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, 730020, Gansu Province, China
    Jiexiang Tian, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, 730020, Gansu Province, China
    Zhonghua Qi, Gansu University of Chinese Medicine, Lanzhou, China
    Menghan Li, Gansu University of Chinese Medicine, Lanzhou, China
    Xingwen Xie, Gansu University of Chinese Medicine, Lanzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.