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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1481989
The role of DC subgroups in the pathogenesis of asthma
Provisionally accepted
Jiangang Xu
1,2*
Shuxian Cao
1,2*
Youhua Xu
1,2*
Han Chen
3*
Siji Nian
1,2
Lin Li
1,2
Qin Liu
1,2*
Wenfeng Xu
1,2
Yingchun Ye
1,2*
Qing Yuan
1,2*- 1 School of Basic Medical Sciences, Southwest Medical University, Luzhou, China
- 2 Public Center of Experimental Technology, Southwest Medical University, Luzhou, Sichuan Province, China
- 3 School of Stomatology, Southwest Medical University, Luzhou, China
Dendritic cells (DCs), specialized antigen-presenting cells of the immune system, act as immunomodulators in diseases of the immune system, including asthma. The understanding of DC biology has evolved over the years to include multiple subsets of DCs with distinct functions in the initiation and maintenance of asthma. Moreover, most strategies for treating asthma with relevant therapeutic agents that target DCs have been initiated from the study of DC function. We discussed the pathogenesis of asthma (including T2-high and T2low), the roles played by different DC subpopulations in the pathogenesis of asthma, and the therapeutic strategies centered around DCs. This study will provide a scientific theoretical basis for current asthma treatment, provide theoretical guidance and research ideas for developing and studying therapeutic drugs targeting DC, and provide more therapeutic options for the patient population with poorly controlled asthma symptoms.
Keywords: Asthma, DC, DC subgroups, Pathogenesis, asthma treatment
Received: 17 Aug 2024; Accepted: 09 Oct 2024.
Copyright: © 2024 Xu, Cao, Xu, Chen, Nian, Li, Liu, Xu, Ye and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiangang Xu, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China
Shuxian Cao, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China
Youhua Xu, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China
Han Chen, School of Stomatology, Southwest Medical University, Luzhou, China
Qin Liu, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China
Yingchun Ye, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China
Qing Yuan, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China
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