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MINI REVIEW article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1479418

STAT4 gene polymorphisms in human diseases

Provisionally accepted
Yan Xia Yan Xia 1Yanni Xie Yanni Xie 1hao zhang hao zhang 1,2Lunzhi Liu Lunzhi Liu 1*
  • 1 Hubei Minzu University, Enshi, China
  • 2 Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center (SDATC), Jinan, Shandong Province, China

The final, formatted version of the article will be published soon.

    Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family, which is a group of transcription factors that regulate cytokine signaling.Genetic polymorphisms in STAT4 strongly influence immune responses and disease outcomes, especially in cancer and autoimmune diseases such as AIDs. Several studies have indicated that certain STAT4 gene variants are associated with alterations in STAT4 expression and/or activity and that there is a close relationship between STAT4 polymorphisms and drug efficacy. However, the underlying mechanisms are complex, and the roles of these polymorphisms in disease acquisition, progression, and severity are of widespread concern. Therefore, we provide an overview of the clinical significance of polymorphisms in STAT4 and the mechanisms by which these STAT4 variants are involved in various diseases.

    Keywords: STAT4, Single nucleotide polymorphism, Clinical significance；, Polymorphisms and therapeutic efficacy, autoimmune disease

    Received: 19 Aug 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Xia, Xie, zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lunzhi Liu, Hubei Minzu University, Enshi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.