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REVIEW article

Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1479330

Macrophage-derived Extracellular Vesicles as New Players in Chronic Non-Communicable Diseases

Provisionally accepted
Fengjuan Lin Fengjuan Lin 1Huiyu Luo Huiyu Luo 1Jiexian Wang Jiexian Wang 1Qing Li Qing Li 2Longying Zha Longying Zha 1*
  • 1 Southern Medical University, Guangzhou, China
  • 2 Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Macrophages are innate immune cells present in all tissues and play an important role in almost all aspects of the biology of living organisms. Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant cells for cell-to-cell communication.Numerous studies have shown that macrophage-derived extracellular vesicles (M-EVs)and their contents play an important role in a variety of diseases and show great potential as biomarkers, therapeutics, and drug delivery vehicles for diseases. This article reviews the biological functions and mechanisms of M-EVs and their contents in chronic non-communicable diseases such as cardiovascular diseases, metabolic diseases, cancer, inflammatory diseases and bone-related diseases. In addition, the potential application of M-EVs as drug delivery systems for various diseases have been summarized.

    Keywords: macrophage-derived extracellular vesicles, Exosomes, biological functions, Drug Delivery Systems, Chronic non-communicable diseases

    Received: 13 Aug 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Lin, Luo, Wang, Li and Zha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Longying Zha, Southern Medical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.