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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1478323

Biological Characteristics and Immune Responses of NK Cells in Commonly Used Experimental Mouse Models

Provisionally accepted
Jingwen Qin Jingwen Qin 1Zhaokai Zhang Zhaokai Zhang 2Haopeng Cui Haopeng Cui 1Jinhua Yang Jinhua Yang 1Aiqun Liu Aiqun Liu 1*
  • 1 Department of Gastroenterology and Respiratory Internal Medicine & Endoscopy Center, Guangxi Medical University Cancer Hospital, Nanning, China
  • 2 Cenxi People's Hospital, Wuzhou, China

The final, formatted version of the article will be published soon.

    The biology of natural killer (NK) cells in commonly used mouse models is discussed in this review, along with their crucial function in a variety of immunological responses. It has been demonstrated that the formation, maturation, subtype variety, and immunological recognition mechanisms of NK cells from various mice strains exhibit notable differences. These variations shed light on the intricacy of NK cell function and offer crucial information regarding their possible uses in treating human illnesses. The application of flow cytometry in mouse NK cell research is also covered in the article. Improved knowledge of the biology of NK cells across species may facilitatelead to the development of new NK cell-based therapeutic approaches.

    Keywords: laboratory mice, Biological characteristics, Surface receptors, Flow Cytometry, Natural killer cells (NK cells)

    Received: 09 Aug 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Qin, Zhang, Cui, Yang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Aiqun Liu, Department of Gastroenterology and Respiratory Internal Medicine & Endoscopy Center, Guangxi Medical University Cancer Hospital, Nanning, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.