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CASE REPORT article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1478205
This article is part of the Research Topic Adaptive Immune Biomarker Signature for Cancer View all 3 articles

MSI-H, EGFR mutation, and ground-glass nodules as diffuse pulmonary hematogenous metastases

Provisionally accepted
  • 1 Beijing Hospital, beijing, China
  • 2 Peking Union Medical College Graduate School, Beijing, China

The final, formatted version of the article will be published soon.

    Key Result: 1. In lung adenocarcinoma, multiple ground-glass nodules can indicate hematogenous metastases rather than synchronous multiple primary lung cancers. 2. For lung adenocarcinoma patients with concurrent Microsatellite Instability-High, EGFR-sensitive mutation, and ground-glass metastatic lesions, treatment with EGFR-Tyrosine Kinase Inhibitors can achieve partial response but with a short progressionfree survival. 3. When a patient's symptoms and imaging findings significantly improve after treatment, a persistently elevated carcinoembryonic antigen level suggests occult metastasis and a poor prognosis.

    Keywords: EGFR, MSI (microsatellite instability), GGN (ground-glass nodule), CEA, lung cancer

    Received: 09 Aug 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 He and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lin Li, Beijing Hospital, beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.