Skip to main content

REVIEW article

Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1477991
This article is part of the Research Topic A New Perspective in Immune Polymorphism (The HLA, KIR, and LILR genes) View all 7 articles

Germline Natural killer cell receptors modulating the T cell response

Provisionally accepted
Laura Mora-Bitria Laura Mora-Bitria Becca Asquith Becca Asquith *
  • Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, England, United Kingdom

The final, formatted version of the article will be published soon.

    In addition to their central role during innate responses, NK cells regulate adaptive immunity through various mechanisms. A wide array of innate receptors has been involved in the NK cell regulatory function. However, the clinical implications of these regulatory pathways are poorly understood. Here, we review the experimental evidence on the effects of NK cells on T cells and their positive and negative consequences for disease outcome during T cell responses in humans.

    Keywords: NK cell regulation, T cell, T cell survival, innate receptor, NK cell

    Received: 08 Aug 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 Mora-Bitria and Asquith. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Becca Asquith, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, W2 1NY, England, United Kingdom

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.