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MINI REVIEW article

Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1476865
This article is part of the Research Topic Exosome-Mediated Intercellular Communications: Immune Stimulation and Suppression View all 7 articles

The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure

Provisionally accepted
Dandan Guo Dandan Guo *Junchen Yan Junchen Yan *Zhenyu Yang Zhenyu Yang Mengzhu Chen Mengzhu Chen *Weibo Zhong Weibo Zhong *Xingxing Yuan Xingxing Yuan Siming Yu Siming Yu *
  • Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China

The final, formatted version of the article will be published soon.

    Heart failure (HF) is a complex and debilitating condition characterized by the heart's inability to pump blood effectively, leading to significant morbidity and mortality. The abnormality of immune response is a key factor in the progression of HF, contributing to adverse cardiac remodeling and dysfunction.Exosomal microRNAs (miRNAs) play a pivotal role in regulating gene expression and cellular function, which are integral to the crosstalk between cardiac and immune cells, influencing immune cell functions, such as macrophage polarization, T cell activity, and cytokine production, thereby modulating various pathological processes of HF, such as inflammation, fibrosis, and cardiac dysfunction. This review emphasizes the immune-regulatory role of exosomal miRNAs in HF and highlights their clinical potential as diagnostic biomarkers and therapeutic agents.

    Keywords: Heart Failure, exosome, miRNA, Immune Modulation, macrophage polarization Abbreviations

    Received: 06 Aug 2024; Accepted: 14 Nov 2024.

    Copyright: © 2024 Guo, Yan, Yang, Chen, Zhong, Yuan and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Dandan Guo, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China
    Junchen Yan, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China
    Mengzhu Chen, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China
    Weibo Zhong, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China
    Siming Yu, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.