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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1476436
This article is part of the Research Topic Unveiling Biomarkers and Mechanisms in the Tumor-Immune Nexus View all 26 articles

Clinical Immunotherapy in Glioma: Current Concepts, Challenges, and Future Perspectives

Provisionally accepted
Jun Liu Jun Liu 1Jingjian Peng Jingjian Peng 2Jian Jiang Jian Jiang 2Yanhui Liu Yanhui Liu 1*
  • 1 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
  • 2 Jiujiang First People's Hospital, Jiujiang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Glioma is one of the common tumors in the central nervous system, and its treatment methods (surgery, radiotherapy, and chemotherapy) lack specificity and have a poor prognosis. With the development of immunology, cell biology, and genomics, tumor immunotherapy has ushered in a new era of tumor therapy, achieving significant results in other invasive cancers such as advanced melanoma and advanced non-small cell lung cancer. Currently, the clinical trials of immunotherapy in glioma are also progressing rapidly. Here, this review summarizes promising immunotherapy methods in recent years, reviews the current status of clinical trials, and discusses the challenges and prospects of glioma immunotherapy.

    Keywords: Immunotherapy, gliomas, tumor vaccines, immune checkpoint inhibitors, car-t, Oncolytic Virotherapy

    Received: 05 Aug 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Liu, Peng, Jiang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yanhui Liu, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.