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CASE REPORT article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1474354

Case Report on Anti-GQ1b Antibody Syndrome: Initial Symptoms of Pupil Palsy and Periorbital Pain

Provisionally accepted
Du Yang Du Yang 1,2Weidong Wang Weidong Wang 1,2*Lili Zhang Lili Zhang 1Yuan Li Yuan Li 1,2*Xiang Chen Xiang Chen 1,2*Xin Ding Xin Ding 1*Hui Yang Hui Yang 3*
  • 1 Department of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan Province, China
  • 2 School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China
  • 3 First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Anti-GQ1b antibody syndrome is a spectrum of autoimmune disorders affecting nervous systems. We report a case of a 53-year-old woman presenting mydriasis with acute onset of periorbital pain, photophobia, and subsequently, diplopia. Despite weakly positive anti-GQ1b IgG antibody, the patient exhibited atypical features with isolated ophthalmoplegia and absence of classic Miller-Fisher syndrome triad. Symptoms improved spontaneously without specific immunotherapy. This case highlights the variable clinical presentations of anti-GQ1b antibody syndrome, emphasizing the importance of considering this diagnosis in patients with unexplained iris abnormalities and ophthalmoplegia.

    Keywords: GQ1b, GQ1b antibody, GQ1b antibody syndrome, Miller Fischer syndrome, Mydriasis, Pain, Opthalmoplegia

    Received: 09 Aug 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Yang, Wang, Zhang, Li, Chen, Ding and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Weidong Wang, Department of Neurology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan Province, China
    Yuan Li, Department of Neurology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan Province, China
    Xiang Chen, Department of Neurology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan Province, China
    Xin Ding, Department of Neurology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan Province, China
    Hui Yang, First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China

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