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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Comparative Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1473686
This article is part of the Research Topic Community Series in Aquatic Nutrition and Intestine Immunity: Volume II View all articles

Comparative study of immune responses and intestinal microbiota in the gut-liver axis between wild and farmed pike perch (Sander Lucioperca)

Provisionally accepted
Jing Wang Jing Wang Shaowu Li Shaowu Li Zhipeng Sun Zhipeng Sun Cuiyun Lu Cuiyun Lu Ran Zhao Ran Zhao Tianqi Liu Tianqi Liu Di Wang Di Wang *Xianhu Zheng Xianhu Zheng *
  • Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Heilongjiang, China

The final, formatted version of the article will be published soon.

    Diets of wild and farmed fish vary greatly. In this study, we measured various immune parameters in the blood, liver and intestine of wild and farmed pike perch to analyze the effects of variations in diet. Gut microbes were also collected for 16S rRNA gene sequencing. Our results showed that the serum low-density lipoprotein cholesterol (LDL-C) levels were twice as high in the wild group as in the farmed group.Furthermore, the activities of glutamate pyruvate transaminase (GPT) and glutamate oxaloacetate transaminase (GOT) in the intestinal tissues of the wild group were 733.91 U/g and 375.35 U/g, which were significantly higher than those of the farmed group. Expression of IL10 in the liver of farmed pike perch was also 4-fold higher than that of wild pike perch. The expression of genes related to the p53-BAX/Bcl2 signaling pathway was higher in both intestinal and liver tissues of wild pike perch compared with farmed.16S rRNA gene analysis of the gut microflora showed a high relative abundance of Cetobacterium in the gut of farmed pike perch. In conclusion, our study indicated that dietary differences affect glycolipid metabolism and immunomodulation in pike perch.

    Keywords: Sander lucioperca, Hematological, Metabolic enzyme, gene expressions, intestinal flora

    Received: 31 Jul 2024; Accepted: 10 Sep 2024.

    Copyright: © 2024 Wang, Li, Sun, Lu, Zhao, Liu, Wang and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Di Wang, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Heilongjiang, China
    Xianhu Zheng, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Heilongjiang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.