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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1470269
This article is part of the Research Topic Deciphering Cancer Metabolism: A New Frontier in Tumor Immunology with Computational Innovation View all 8 articles

Lipidome Analyses Reveal Radiation Induced Remodeling of Glycerophospholipid Unsaturation in Lung Tumor

Provisionally accepted
Jingquan He Jingquan He 1Qingqing Yuan Qingqing Yuan 2Song Gao Song Gao 1*Yue Wang Yue Wang 3*Haigen Lai Haigen Lai 1*Kaiting Wang Kaiting Wang 1*Xiaoman Zhou Xiaoman Zhou 1*Zicheng Zhang Zicheng Zhang 1*
  • 1 Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
  • 2 Cancer Hospital & Shenzhen Hospital, Shenzhen, China
  • 3 Shenzhen Luohu People's Hospital, Shenzhen, China

The final, formatted version of the article will be published soon.

    Radiotherapy is a pivotal treatment for lung cancer, significantly impacting tumor control and patient quality of life. Despite its benefits, the molecular mechanisms underlying radiotherapy-induced biological alterations in lung cancer cells remain inadequately understood. In this study, we employed a mass spectrometry-based lipidomics approach to investigate lipid profile changes in a lung cancer mouse model post-radiation. Lewis lung carcinoma (LLC) cells were injected into C57BL/6J mice, followed by radiation treatment with varying split doses. Our results showed an increase in sterol lipids and a decrease in glycerolipids, specifically triacylglycerides, indicating disrupted lipid storage. Additionally, we observed significant changes in glycerophospholipid unsaturation, suggesting a remodeling of membrane properties that may influence cell survival. Linear regression analysis demonstrated a significant negative correlation between glycerophospholipid unsaturation index and tumor weight, indicating a potential role in radiation-induced tumor cell death. These findings provide new insights into the lipid metabolic pathways affected by radiotherapy and could inform the development of improved therapeutic strategies for lung cancer treatment.

    Keywords: lung cancer, Radiotherapy, lipidomics, Glycerophospholipids, lipid unsaturation

    Received: 25 Jul 2024; Accepted: 08 Oct 2024.

    Copyright: © 2024 He, Yuan, Gao, Wang, Lai, Wang, Zhou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Song Gao, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
    Yue Wang, Shenzhen Luohu People's Hospital, Shenzhen, 518001, China
    Haigen Lai, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
    Kaiting Wang, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
    Xiaoman Zhou, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
    Zicheng Zhang, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.