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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1470269
This article is part of the Research Topic Deciphering Cancer Metabolism: A New Frontier in Tumor Immunology with Computational Innovation View all 8 articles
Lipidome Analyses Reveal Radiation Induced Remodeling of Glycerophospholipid Unsaturation in Lung Tumor
Provisionally accepted- 1 Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
- 2 Cancer Hospital & Shenzhen Hospital, Shenzhen, China
- 3 Shenzhen Luohu People's Hospital, Shenzhen, China
Radiotherapy is a pivotal treatment for lung cancer, significantly impacting tumor control and patient quality of life. Despite its benefits, the molecular mechanisms underlying radiotherapy-induced biological alterations in lung cancer cells remain inadequately understood. In this study, we employed a mass spectrometry-based lipidomics approach to investigate lipid profile changes in a lung cancer mouse model post-radiation. Lewis lung carcinoma (LLC) cells were injected into C57BL/6J mice, followed by radiation treatment with varying split doses. Our results showed an increase in sterol lipids and a decrease in glycerolipids, specifically triacylglycerides, indicating disrupted lipid storage. Additionally, we observed significant changes in glycerophospholipid unsaturation, suggesting a remodeling of membrane properties that may influence cell survival. Linear regression analysis demonstrated a significant negative correlation between glycerophospholipid unsaturation index and tumor weight, indicating a potential role in radiation-induced tumor cell death. These findings provide new insights into the lipid metabolic pathways affected by radiotherapy and could inform the development of improved therapeutic strategies for lung cancer treatment.
Keywords: lung cancer, Radiotherapy, lipidomics, Glycerophospholipids, lipid unsaturation
Received: 25 Jul 2024; Accepted: 08 Oct 2024.
Copyright: © 2024 He, Yuan, Gao, Wang, Lai, Wang, Zhou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Song Gao, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
Yue Wang, Shenzhen Luohu People's Hospital, Shenzhen, 518001, China
Haigen Lai, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
Kaiting Wang, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
Xiaoman Zhou, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
Zicheng Zhang, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
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