AUTHOR=Chen Yukun , Wang Zhenzhi , Zhang Chi , Su Yisa , Zhou Tian , Hu Kaiwen 

TITLE=Revealing the mechanism of natural product-induced immunogenic cell death: opening a new chapter in tumor immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1470071

DOI=10.3389/fimmu.2024.1470071

ISSN=1664-3224

ABSTRACT=<p>This review underscores the role of natural products in inducing immunogenic cell death (ICD) as a key strategy in tumor immunotherapy. It reveals that natural products can activate ICD through multiple pathways—apoptosis, autophagy, pyroptosis, and necroptosis—leading to the release of danger-associated molecular patterns (DAMPs), dendritic cell activation, and improved antigen presentation, which together stimulate a potent anti-tumor immune response. The study also demonstrates the enhanced therapeutic potential of combining natural products with immune checkpoint inhibitors. With a focus on translating preclinical findings into clinical practice, this review consolidates recent discoveries and suggests future research paths, offering both theoretical insights and practical guidance for advancing cancer immunotherapy.</p>