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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1470071

Revealing the mechanism of natural product-induced immunogenic cell death: opening a new chapter in tumor immunotherapy

Provisionally accepted
Yukun Chen Yukun Chen 1*Zhen-zhi Wang Zhen-zhi Wang 2Chi Zhang Chi Zhang 1Yisa Su Yisa Su 1Tian Zhou Tian Zhou 1Kaiwen Hu Kaiwen Hu 1
  • 1 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China
  • 2 Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    This review underscores the role of natural products in inducing immunogenic cell death (ICD) as a key strategy in tumor immunotherapy. It reveals that natural products can activate ICD through multiple pathways-apoptosis, autophagy, pyroptosis, and necroptosis-leading to the release of danger-associated molecular patterns (DAMPs), dendritic cell activation, and improved antigen presentation, which together stimulate a potent anti-tumor immune response.The study also demonstrates the enhanced therapeutic potential of combining natural products with immune checkpoint inhibitors. With a focus on translating preclinical findings into clinical practice, this review consolidates recent discoveries and suggests future research paths, offering both theoretical insights and practical guidance for advancing cancer immunotherapy.

    Keywords: Natural Products, ICD, Tumor immunotherapy, tumor, Cancer

    Received: 25 Jul 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Chen, Wang, Zhang, Su, Zhou and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yukun Chen, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.