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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1469918
This article is part of the Research Topic Non-coding RNAs in disease development and progression View all 4 articles
Long non-coding RNAs are involved in the crosstalk between cancerassociated fibroblasts and tumor cells
Provisionally accepted
Chenbo Yang
1,2
Jiao Shu
1,2*
Yiwei Li
1,2*
Na Zhao
1,2*
Xiaonan Liu
1,2*
Xiangyu Tian
1,2
Zexin Sun
1,2*
Muhammad Saud Tabish
1,2*
Yichen Hong
1,2*
Kuisheng Chen
1,2*
Miaomiao Sun
1,2*- 1 First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
- 2 Henan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, Henan Province, China
The proliferation of tumors is not merely self-regulated by the cancer cells but is also intrinsically connected to the tumor microenvironment (TME). Within this complex TME, cancer-associated fibroblasts (CAFs) are pivotal in the modulation of tumor onset and progression. Rich signaling interactions exist between CAFs and tumor cells, which are crucial for tumor regulation. Long non-coding RNAs (LncRNAs) emerge from cellular transcription as a class of functionally diverse RNA molecules. Recent studies have revealed that LncRNAs are integral to the crosstalk between CAFs and tumor cells, with the capacity to modify cellular transcriptional activity and secretion profiles, thus facilitating CAFs activation, tumor proliferation, metastasis, drug resistance, and other related functionalities. This comprehensive review revisits the latest research on LncRNA-mediated interactions between CAFs and tumor cells, encapsulates the biological roles of LncRNAs, and delves into the molecular pathways from a broader perspective, aspiring to offer novel perspectives for a deeper comprehension of the etiology of tumors and the enhancement of therapeutic approaches.
Keywords: long non-coding RNA, cancer-associated fibroblasts, Tumor Microenvironment, signaling pathway, Tumor growth
Received: 24 Jul 2024; Accepted: 22 Nov 2024.
Copyright: © 2024 Yang, Shu, Li, Zhao, Liu, Tian, Sun, Tabish, Hong, Chen and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiao Shu, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Yiwei Li, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Na Zhao, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Xiaonan Liu, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Zexin Sun, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Muhammad Saud Tabish, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Yichen Hong, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Kuisheng Chen, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
Miaomiao Sun, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
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