AUTHOR=Zhong Xiaotian , Zheng Huiling , Zhao Shiqing , Wang Ziye , Su Yi , Zhong Kaili , Wang Mopei , Shi Yanyan 

TITLE=Effects and mechanisms of Helicobacter pylori on cancers development and immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1469096

DOI=10.3389/fimmu.2024.1469096

ISSN=1664-3224

ABSTRACT=<p>Tumor immunotherapy has been widely used in clinical treatment of various cancers. However, some patients of these cancers do not respond to immunotherapy effectively. And <italic>H. pylori</italic> infection has been considered to be related to the efficacy of immunotherapy. This review aims to summarize the different effects and mechanisms of <italic>H. pylori</italic> infection on immunotherapy in different kinds of cancers. We searched the relevant literature on <italic>H. pylori</italic> and tumor immunotherapy, and summarized to form a review. Generally, <italic>H. pylori</italic> infection plays a role in affecting kinds of cancers’ development, besides gastric cancer. Current evidence suggests that <italic>H. pylori</italic> infection may reduce the efficacy of immunotherapy for colorectal cancer, non-small cell lung cancer and melanoma, but due to the lack of sufficient evidence, more data is needed to prove that. While for gastric cancer, the effects remain controversial. The <italic>H. pylori</italic> regulation effects and metabolisms involved in systematic related cancers should be paid attention to. Whether <italic>H. pylori</italic> should be eradicated when immunotherapy performed may be a critical consideration for some kinds of tumors.</p>