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CORRECTION article

Front. Immunol., 05 September 2024
Sec. Primary Immunodeficiencies
Volume 15 - 2024 | https://doi.org/10.3389/fimmu.2024.1467807

Corrigendum: Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency

This article is a correction to:

  1. Abnormalities of Thymic Stroma may Contribute to Immune Dysregulation in Murine Models of Leaky Severe Combined Immunodeficiency

    1. Read original article
Francesca RucciFrancesca Rucci1Pietro Luigi PolianiPietro Luigi Poliani2Stefano CaraffiStefano Caraffi1Tiziana PaganiniTiziana Paganini3Elena FontanaElena Fontana2Silvia GilianiSilvia Giliani3Frederick W. AltFrederick W. Alt4Luigi Daniele Notarangelo*Luigi Daniele Notarangelo1*
  • 1Division of Immunology and The Manton Center for Orphan Disease Research, Children’s Hospital Boston, Boston, MA, United States
  • 2Department of Pathology, University of Brescia, Brescia, Italy
  • 3“Angelo Nocivelli” Institute for Molecular Medicine and Department of Pediatrics, University of Brescia, Brescia, Italy
  • 4Howard Hughes Medical Institute, Children’s Hospital, Immune Disease Institute and Harvard Medical School, Boston, MA, United States

A Corrigendum on
Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency

By Rucci F, Poliani PL, Caraffi S, Paganini T, Fontana E, Giliani S, Alt FW and Notarangelo LD (2011). Front. Immun. 2:15. doi: 10.3389/fimmu.2011.00015

In the published article, there was an error in Figure 5 as published.

“The insets within the right upper and middle panels showing a higher magnification of the AIRE immunostaining have been corrected. In the original panels, there was a mistake in placing the original insets from a higher magnification image.”

The corrected Figure 5 and its caption appear below.

Figure 5
www.frontiersin.org

Figure 5. Maturation of medullary thymic epithelial cells (mTECs) in wild-type (WT), Lig4R/R, and Rag1S/S mice. Mature mTECs from WT mice express claudin-4 (Cld4), Ulex europaeus agglutinin 1 (UEA-1) and Aire (upper panels). Insets highlight fully mature mTECs showing immunoreactivity (IR) for Cld4 and the characteristic granular dot-like Aire positivity in the nuclei. Thymuses from Lig4R/R mice show residual presence of mTECs that reach full maturation with positivity for UEA-1, Cld4, and Aire expression (middle panels). Loss of corticomedullary demarcation (CMD) with impaired maturation of mTECs was observed in the thymuses from the Rag1S/S mice in which only rare UEA-1 IR cells but no mature Cld4+ and Aire+ cells were found (lower panels). IR staining: brown. All panels are from 20× original magnification; insets are from 40× original magnification. One representative example of five mice analyzed per each strain.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: severe combined immunodeficiency, recombination-activating gene 1, DNA ligase 4, thymic epithelial cells, thymus, dendritic cells, Aire, regulatory T cells

Citation: Rucci F, Poliani PL, Caraffi S, Paganini T, Fontana E, Giliani S, Alt FW and Notarangelo LD (2024) Corrigendum: Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency. Front. Immunol. 15:1467807. doi: 10.3389/fimmu.2024.1467807

Received: 20 July 2024; Accepted: 09 August 2024;
Published: 05 September 2024.

Edited and Reviewed by:

Menno C. van Zelm, Monash University, Australia

Copyright © 2024 Rucci, Poliani, Caraffi, Paganini, Fontana, Giliani, Alt and Notarangelo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Luigi Daniele Notarangelo, luigi.notarangelo@childrens.harvard.edu

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.