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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1467151

LncRNAs in tumor metabolic reprogramming and tumor microenvironment remodeling

Provisionally accepted
Jianhang Jiao Jianhang Jiao 1Yangzhi Zhao Yangzhi Zhao 2Qimei Li Qimei Li 3Shunzi Jin Shunzi Jin 4Zhongshan Liu Zhongshan Liu 3,5*
  • 1 Department of Orthopedics, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
  • 2 Department of Hematology, First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
  • 3 Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
  • 4 Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin Province, China
  • 5 Department of Radiotherapy, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    The tumor microenvironment (TME) is a complex and dynamic ecosystem composed of tumor cells, immune cells, supporting cells, and the extracellular matrix. Typically, the TME is characterized by an immunosuppressive state. To meet the demands of rapid proliferation, cancer cells undergo metabolic reprogramming, which enhances their biosynthesis and bioenergy supply. Immune cells require similar nutrients for activation and proliferation, leading to competition and immunosuppression within the TME. Additionally, tumor metabolites inhibit immune cell activation and function. Consequently, an immunosuppressed and immune-tolerant TME promotes cancer cell proliferation and metastasis. Long non-coding RNAs (lncRNAs), a category of non-coding RNA longer than 200 nucleotides, regulate tumor metabolic reprogramming by interacting with key enzymes, transporters, and related signaling pathways involved in tumor metabolism. Furthermore, lncRNAs can interact with both cellular and non-cellular components in the TME, thereby facilitating tumor growth, metastasis, drug resistance, and inducing immunosuppression. Recent studies have demonstrated that lncRNAs play a crucial role in reshaping the TME by regulating tumor metabolic reprogramming. In this discussion, we explore the potential mechanisms through which lncRNAs regulate tumor metabolic reprogramming to remodel the TME. Additionally, we examine the prospects of lncRNAs as targets for anti-tumor therapy and as biomarkers for tumor prognosis.

    Keywords: lncRNAs, metabolic reprogrammig, Tumor microenvironment remodeling, tumor immunity, Tumor immunotherapy

    Received: 19 Jul 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Jiao, Zhao, Li, Jin and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhongshan Liu, Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.